| Description | Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and peripheral resistance and producing fluid retention. |
| Synonyms | 吡那地尔, S 1230, P 1134, S-1230, P-1134, P1134 |
| molecular weight | 245.32 |
| Molecular formula | C13H19N5 |
| CAS | 60560-33-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (407.63 mM), Sonication is recommended. |
| References | 1. Friedel HA, Brogden RN. Pinacidil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the treatment of hypertension. Drugs. 1990 Jun;39(6):929-67. Review. PubMed PMID: 2196168. 2. Ahnfelt-Rønne I. Pinacidil. Preclinical investigations. Drugs. 1988;36 Suppl 7:4-9. Review. PubMed PMID: 3076134. 3. Cohen ML, Kurz KD. Pinacidil-induced vascular relaxation: comparison to other vasodilators and to classical mechanisms of vasodilation. J Cardiovasc Pharmacol. 1988;12 Suppl 2:S5-9. PubMed PMID: 2466179. 4. Zushida K, Onodera K, Kamei J. Effect of diabetes on pinacidil-induced antinociception in mice. Eur J Pharmacol. 2002 Oct 25;453(2-3):209-15. PubMed PMID: 12398906. |