| Description | PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM). |
| In vitro | PI3Kδ-IN-1 具有改良的人类/啮齿动物体外稳定性相关性，并展现出良好的渗透性特征[1]。 |
| In vivo | PI3Kδ-IN-1 在小鼠实验中显示出超过50%的抑制肿胀效果。在24小时内，PI3Kδ-IN-1 在小鼠中的EC50值为10 nM（ED50约为1.25 mg/kg）[1]。 |
| Target activity | PI3Kδ:1.7 nM |
| molecular weight | 471.44 |
| Molecular formula | C22H20F3N7O2 |
| CAS | 1911564-39-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 18.0 mg/mL (37.6 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Liu Q, et al. Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders. J Med Chem. 2017 Jun 22;60(12):5193-5208. |