| Description | Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) . |
| In vivo | 在糖尿病,肥胖症,以及应激性高血糖的治疗中,Phlorizin通过抑制位于近端肾小管和小肠粘膜的钠离子-葡萄糖协同转运子,产生肾脏糖尿并阻断肠道葡萄糖的吸收。 |
| Target activity | SGLT1 (human):300 nM(Ki), SGLT2 (human):39 nM(Ki) |
| Synonyms | Floridzin, 根皮甙, 根皮苷, NSC 2833, Phloridzin |
| molecular weight | 436.41 |
| Molecular formula | C21H24O10 |
| CAS | 60-81-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 43.6 mg/mL (100 mM) DMSO: 60 mg/mL (137.49 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Taton J, et al. Endokrynol Pol, 2010, 61(3), 303-310. 2. Ehrenkranz JR, et al. Diabetes Metab Res Rev, 2005, 21(1), 31-38. 3. Shim K S, Hwang Y H, Jang S A, et al. . Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice[J]. Nutrients. 2020, 12(7): 1927. 4. Chen Q, Sun D, Fang T, et al. In vitro allelopathic effects of compounds from Cerbera manghas L. on three Dinophyta species responsible for harmful common red tides. Science of The Total Environment. 2020: 142253. |
| Citations | 1. Shim K S, Hwang Y H, Jang S A, et al. Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice. Nutrients. 2020, 12(7): 1927 2. Tsang C C, Tang J Y M, Ye H, et al. Rare/cryptic Aspergillus species infections and importance of antifungal susceptibility testing. Mycoses. 2020, 63(12): 1283-1298 |