| Description | PF 03716556 (PF-3716556) , an effective and specific P-CAB (potassium-competitive acid blocker), is utilized for the treatment of gastroesophageal reflux disease. |
| In vitro | PF 03716556对不同的物种如猪,犬和人类的酶没有选择性差异性.在大鼠和狗动物模型中,PF 03716556抑制胃酸分泌. |
| In vivo | PF 03716556对H+（pIC50=6.026）,K+-ATPase（pIC50=7.095）具有高度选择性。 |
| Target activity | H+, K+-ATPase:6.5(pIC50) |
| Synonyms | PF-3716556 |
| molecular weight | 394.47 |
| Molecular formula | C22H26N4O3 |
| CAS | 928774-43-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 39.5 mg/mL (100 mM) |
| References | 1. Mori H, et al. J Pharmacol Exp Ther, 2009, 328(2), 671-679. |