| Description | PF-9404C is the S-S diesteroisomer of a beta adrenergic receptors blocker with vasodilatory properties. PF9404C increased the formation of cyclic GMP from 3 pmol mg−1 protein in basal conditions, to 53 pmol mg−1 protein in 10 μM in rat aorta smooth muscle cells. |
| Synonyms | PF9404C |
| molecular weight | 403.38 |
| Molecular formula | C16H25N3O9 |
| CAS | 780825-97-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Villarroya M, López MG, de Pascual R, García AG. Preclinical profile of PF9404C, a nitric oxide donor with beta receptor blocking properties. Cardiovasc Drug Rev. 2005 Summer;23(2):149-60. Review. PubMed PMID: 16007231. 2. Ruiz-Nuño A, Rosado A, García AG, López MG, Villarroya M. Differences in the vascular selectivity and tolerance between the NO donor/beta-blocker PF9404C and nitroglycerin. Eur J Pharmacol. 2004 Sep 13;498(1-3):203-10. PubMed PMID: 15363996. 3. Villarroya M, Herrero CJ, Ruíz-Nuño A, de Pascual R, del Valle M, Michelena P, Grau M, Carrasco E, López MG, García AG. PF9404C, a new slow NO donor with beta receptor blocking properties. Br J Pharmacol. 1999 Dec;128(8):1713-22. PubMed PMID: 10588927; PubMed Central PMCID: PMC1571821. |