| Description | PF 06446846 is a potent and selective PCSK9 inhibitor |
| In vivo | PF-06446846 在口服给药后能够降低大鼠的血浆PCSK9及总胆固醇水平。该化合物对于抑制PCSK9的翻译具有高度的选择性。PF-06446846所采用的作用机理揭示了人类核糖体之前未被预料到的可调控性，这种性质允许小分子特异性地阻断个别转录本的翻译。 |
| molecular weight | 433.89 |
| Molecular formula | C22H20ClN7O |
| CAS | 1632250-49-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.34 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Lintner N G , Mcclure K F , Donna P , et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain[J]. PLoS Biology, 2017, 15(3):e2001882-. |