| Description | LJP-1586 HCl, a highly selective inhibitor of vascular adhesion protein-1 (VAP-1), exhibits antiinflammation effect by reducing adhesion molecule expression and immune cell infiltration after intracerebral hemorrhage (ICH). |
| Synonyms | LJP 1586, LJP-1586 hydrochloride, LJP-1586, LJP1586 |
| molecular weight | 231.69 |
| Molecular formula | C11H15ClFNO |
| CAS | 955037-42-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 40 mg/mL, Sonication is recommended. |
| References | 1. Filip A, et al. Expression of the semicarbazide-sensitive amine oxidase in articular cartilage: its role in terminal differentiation of chondrocytes in rat and human. Osteoarthritis Cartilage. 2016 Jul;24(7):1223-34. 2. Xu H, et al. VAP-1 blockade prevents subarachnoid hemorrhage-associated cerebrovascular dilating dysfunction via repression of a neutrophil recruitment-related mechanism. Brain Res. 2015 Apr 7;1603:141-9. 3. Xu HL, et al. Pharmacologic blockade of vascular adhesion protein-1 lessens neurologic dysfunction in rats subjected to subarachnoid hemorrhage. Brain Res. 2014 Oct 24;1586:83-9. 4. Watcharotayangul J, et al. Post-ischemic vascular adhesion protein-1 inhibition provides neuroprotection in a rat temporary middle cerebral artery occlusion model. J Neurochem. 2012 Nov;123 Suppl 2:116-24. |