| Description | Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are not released from infected cells. Peramivir Trihydrate is a cyclopentane derivative with activity against influenza A and B viruses. |
| In vitro | Peramivir（0.025-0.1 mg/kg/day）和法匹拉韦（20-40 mg/kg/day）联用时增加10-50%细胞存活率.Peramivir（0.5 mg/kg/day）对30%的H1N1病毒小鼠有保护效果.Peramivir（1 mg/kg/day）和金刚烷乙胺（5-10 mg/kg/day）联用使体重分别损失1.69和0.69,但在亚致死流感A（H3N2）病毒的小鼠模型中,每天3 mg/kg Peramivir（3 mg/kg/day）和Rimantadine（10-30 mg/kg/day）联用则不影响体重.Peramivir（30 mg/kg）能有效促进感染全身复制H5N1病毒小鼠的生存期. |
| Target activity | Neuraminidase:0.09 nM |
| Synonyms | RWJ-270201, 帕拉米韦三水合物, S-021812, BCX-1812, RWJ 270201 trihydrate, BCX 1812 trihydrate |
| molecular weight | 382.45 |
| Molecular formula | C15H28N4O4·3H2O |
| CAS | 1041434-82-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 6.6 mg/mL (17.26 mM), Sonication is recommended. |
| References | 1. Yun NE, et al. Virology, 2008, 374(1), 198-209. 2. Smee DF, et al. Antiviral Res, 2010, 88(1), 38-44. 3. Boltz DA, et al. Antiviral Res, 2008, 80(2), 150-157. 4. Tarbet EB, et al. Antiviral Res, 2012, 94(1), 103-110. 5. Bantia S, et al. Antiviral Res, 2010, 88(3), 276-280. |