| Description | Peptide T acetate is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a synthetic octapeptide whose possible mechanism of action is the competitive inhibition of gp120 to the CD4 receptor as well as binding to vasointestinal peptide receptors and inhibiting cytokine action |
| In vitro | Peptide T通过抑制MAGI细胞测定中的病毒进入并在使用ADA外壳伪装的HIV病毒颗粒的荧光素酶报告测定中阻断感染来发挥作用。Peptide T选择性地通过趋化因子受体CCR5而非CXC4抑制HIV复制[2]。在10^-8 M浓度下，Peptide T诱导人类Th2细胞系和PBMC产生IL-10。同样，在10^-9 M浓度下，Peptide T显著抑制PBMC产生IFN-g[3]。 |
| In vivo | Peptide T通过皮下注射的方式，在实验性自身免疫性脑脊髓炎(EAE)病程的不同阶段和剂量进行给药，然而，Peptide T既不能预防也不能改善EAE[4]的病情。 |
| molecular weight | 917.91 |
| Molecular formula | C37H59N9O18 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 5 mM DMSO: Insoluble |
| References | 1. Ruff MR, et al. Peptide T[4-8] is core HIV envelope sequence required for CD4 receptor attachment. Lancet. 1987 Sep 26;2(8561):751. |