| Description | PD150606 is a selective nonpeptide calpain inhibitor with neuroprotective activity that inhibits μ-calpains and m-calpains.Inhibits erythrocyanine-induced Ca2+ efflux and interferes with excitotoxicity-dependent motor neuron death. |
| In vitro | PD 150606 (25 μM；0-12 小时) 能在一定程度减少放线菌酮诱导的中性粒细胞凋亡[2]。 |
| Target activity | μ-Calpain:0.21 μM (Ki), m-Calpain:0.37 μM (Ki) |
| molecular weight | 306.12 |
| Molecular formula | C9H7IO2S |
| CAS | 179528-45-1 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 15 mg/mL (49.00 mM), Sonification is recommended. |
| References | 1. Wang KK et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92. 2. Squier MK , et al. Calpain and calpastatin regulate neutrophil apoptosis. J Cell Physiol. 1999 Mar;178(3):311-9. |