| Description | PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively. |
| In vitro | PD 90780（0.1-100 μM；2小时）影响125I-BDNF与截短型p75NTR的结合。PD 90780（100 μM；2小时）抑制125I-NGF与p75NTR的交联。PD 90780（0-300 μM；2小时）随着剂量增至300 μM，降低因NGF结合而导致的TrkA磷酸化。PD 90780（0.1-100 μM；2小时）抑制NGF与p75NTR的相互作用，其中在PC12细胞和PC12nnr5细胞中的IC50值分别为23.1 µM和1.8 µM[1]。 |
| Target activity | NGF (PC12 nnr5 cells):1.8 µM , NGF (PC12 cells):23.1 µM |
| molecular weight | 362.34 |
| Molecular formula | C19H14N4O4 |
| CAS | 77422-99-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 28.8 mg/mL (79.5 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Colquhoun A , et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J Pharmacol Exp Ther. 2004 Aug;310(2):505-11. |