| Description | PD 117302 is a nonpeptide opioid compound. It is a selective kappa-opioid agonist. PD 117302 causes naloxone-reversible locomotor impairment and diuresis. It is an Anti-Arrhythmia Agent, an Anticonvulsants, a Cardiovascular Agent, and a Central Nervous System Agent. |
| Synonyms | PD-117302, PD117302 |
| molecular weight | 356.53 |
| Molecular formula | C21H28N2OS |
| CAS | 111728-01-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Leighton GE, Hill RG, Hughes J. The effects of the kappa agonist PD-117302 on feeding behaviour in obese and lean Zucker rats. Pharmacol Biochem Behav. 1988 Oct;31(2):425-9. PubMed PMID: 2854265. 2. Leighton GE, Johnson MA, Meecham KG, Hill RG, Hughes J. Pharmacological profile of PD 117302, a selective kappa-opioid agonist. Br J Pharmacol. 1987 Dec;92(4):915-22. PubMed PMID: 2827830; PubMed Central PMCID: PMC1853714. 3. Colombo M, Petrillo P, La Regina A, Bianchi G, Tavani A. In vitro binding profile and in vivo pharmacological properties of the K-opioid compound PD 117302. Res Commun Chem Pathol Pharmacol. 1991 Jun;72(3):295-306. PubMed PMID: 1658887. 4. Porreca F, Ianone M, Wheeler H, Cowan A. Comparison of PD 117302, a kappa agonist, and morphine on colonic transit and formalin-induced pain in rats. Proc West Pharmacol Soc. 1989;32:185-7. PubMed PMID: 2550944. |