| Description | PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer. |
| In vitro | PCNA-I1 在LNCaP和PC-3细胞中引发了DNA损伤与凋亡，并增强了顺铂引起的DNA损伤与凋亡。PCNA-I1还在PC-3细胞中诱发了自噬。短期预处理PCNA-I1在两种细胞系中减少了50%的集落形成。[1] |
| In vivo | 经静脉给药PCNA-I1显著抑制了裸鼠体内LNCaP肿瘤的生长，而未对小鼠体重和血液学特征造成可检测的影响[1]。 |
| molecular weight | 310.37 |
| Molecular formula | C17H14N2O2S |
| CAS | 444930-42-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 3.1 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Dillehay K L , Lu S , Dong Z . Antitumor Effects of a Novel Small Molecule Targeting PCNA Chromatin Association in Prostate Cancer[J]. Molecular Cancer Therapeutics, 2014, 13(12):2817-26. 2. Dillehay K L , Seibel W L , Zhao D , et al. Target validation and structure–activity analysis of a series of novel PCNA inhibitors[J]. Pharmacology Research & Perspectives, 2015, 3(2). |