| Description | PBP2 is a selective inducer of G-quadruplex structures from the unstructured single-stranded DNA conformations. PBP2 downregulates BCL-2 gene expression in cancer cells. |
| Synonyms | PBP-2, PBP 2 |
| molecular weight | 804.92 |
| Molecular formula | C40H48N14O5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lange F, Pfennigwerth N, Höfken LM, Gatermann SG, Kaase M. Characterization of mutations in Escherichia coli PBP2 leading to increased carbapenem MICs. J Antimicrob Chemother. 2018 Nov 27. doi: 10.1093/jac/dky476. [Epub ahead of print] PubMed PMID: 30496417. 2. Rohs PDA, Buss J, Sim SI, Squyres GR, Srisuknimit V, Smith M, Cho H, Sjodt M, Kruse AC, Garner EC, Walker S, Kahne DE, Bernhardt TG. A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery. PLoS Genet. 2018 Oct 18;14(10):e1007726. doi: 10.1371/journal.pgen.1007726. eCollection 2018 Oct. PubMed PMID: 30335755; PubMed Central PMCID: PMC6207328. 3. Thakur SD, Levett PN, Horsman GB, Dillon JR. Association of Neisseria gonorrhoeae genogroups and specific PBP2/MtrR/PorB mutation patterns with susceptibility to penicillin in a susceptible gonococcal population. J Antimicrob Chemother. 2018 Oct 1;73(10):2682-2686. doi: 10.1093/jac/dky233. PubMed PMID: 29992304. 4. Ábrók M, Lázár A, Szécsényi M, Deák J, Urbán E. Combination of MALDI-TOF MS and PBP2' latex agglutination assay for rapid MRSA detection. J Microbiol Methods. 2018 Jan;144:122-124. doi: 10.1016/j.mimet.2017.11.021. Epub 2017 Nov 24. PubMed PMID: 29180272. |