| Description | PARP/EZH2-IN-1 is a novel compound that functions as a dual inhibitor for both PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM), showing promising potential for the treatment of triple-negative breast cancer with wild-type BRCA. |
| Target activity | PARP1:6.87 nM (IC50), EZH2:36.51 nM (IC50) |
| Synonyms | PARP/EZH2-IN-1 |
| molecular weight | 768.85 |
| Molecular formula | C43H41FN8O5 |
| CAS | 2687273-52-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Wang C, et al. Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA. J Med Chem. 2021 Sep 9;64(17):12630-12650. |