| Description | PACOCF3 (Palmityltrifluoromethylketone) (Palmityltrifluoromet hylketone) is an inhibitor of Ca(2+)-independent phospholipase A2(PLA2) with an IC 50 of 3.8 μM. PACOCF3 alters Ca 2+ signaling in renal tubular cells [1] [2]. |
| In vitro | PACOCF3 does not change basal cytosolic free calcium concentrations ([Ca 2+ ] i ) at a concentration of 20 μM, while at concentrations of 50-250 μM PACOCF3 induced an increase in [Ca 2+ ] i by activating extracellular Ca 2+ entry which is partly suppressed by 50 μM La3+ [2]. The effect of PACOCF3 is abolished by removal of extracellular Ca 2+. PACOCF3 (10 μM) enhances both the peak value and the area under the curve of the [Ca 2+ ] i increase induced by 10 μM ATP and 1 μM bradykinin by potentiating extracellular Ca 2+ influx without affecting internal Ca 2+ release [2]. |
| Synonyms | 1,1,1-trifluoroheptadecan-2-one, Palmityltrifluoromethylketone |
| molecular weight | 308.42 |
| Molecular formula | C17H31F3O |
| CAS | 141022-99-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (145.9 mM), Sonication is recommended. |
| References | 1. E J Ackermann, et al. Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem. 1995 Jan 6;270(1):445-50. 2. C R Jan, et al. Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch Toxicol. 2000 Oct;74. |