| Description | P32/98 hemifumarate is a dipeptidyl peptidase IV (DPP4) inhibitor with hypoglycemic properties that improves insulin sensitivity and β-cell responsiveness in the Zucker diabetic rat model, and may be useful in studies of type 2 diabetes and colitis. |
| In vitro | 在猪近曲小管细胞中，P32/98 (hemifumarate)（10 μM;96 小时）没有显示出细胞毒性[2]。 |
| In vivo | 在 Zucker 糖尿病肥胖大鼠中，P32/98 (hemifumarate)（25 mg/kg;口服灌注;每日一次）能够显著改善 Zucker 糖尿病肥胖大鼠的葡萄糖耐量[3]。 |
| Synonyms | P32/98 (hemifumarate)(136259-20-6 free base) |
| molecular weight | 520.71 |
| Molecular formula | C22H40N4O6S2 |
| CAS | 251572-86-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Augstein P, et al. Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance. Diabetes Obes Metab. 2008;10(10):850-861. 2. Schlatter P, et al. Glucagon-like peptide 1 receptor expression in primary porcine proximal tubular cells. Regul Pept. 2007 Jun 7;141(1-3):120-8. 3. Wargent E, et al. Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone. Diabetes Obes Metab. 2005;7(2):170-181. |