| Description | Diprotin A (Ile-Pro-Ile) (Ile-Pro-Ile) is a dipeptidyl peptidase IV (DPP-IV) inhibitor. |
| Synonyms | Ile-Pro-Ile, 抑二肽素A |
| molecular weight | 341.45 |
| Molecular formula | C17H31N3O4 |
| CAS | 90614-48-5 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/mL (161.08 mM) |
| References | 1. Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393. 2. Chakraborty C, Hsu MJ, Agoramoorthy G. Understanding the molecular dynamics of type-2 diabetes drug target DPP-4 and its interaction with Sitagliptin and inhibitor Diprotin-A. Cell Biochem Biophys. 2014 Nov;70(2):907-22. doi: 10.1007/s12013-014-9998-0. PubMed PMID: 24809328. 3. Zhang D, Huang W, Dai B, Zhao T, Ashraf A, Millard RW, Ashraf M, Wang Y. Genetically manipulated progenitor cell sheet with diprotin A improves myocardial function and repair of infarcted hearts. Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1339-47. doi: 10.1152/ajpheart.00592.2010. Epub 2010 Aug 27. PubMed PMID: 20802132; PubMed Central PMCID: PMC2993193. 4. Krupina NA, Khlebnikova NN. Omega-3 polyunsaturated fatty acids when administered to lactating rats modify the development of experimental anxiety-depressive state in the rat pups exposed to the dipeptidyl peptidase-IV inhibitor diprotin A on the second - third weeks after the birth. Patol Fiziol Eksp Ter. 2016 Oct-Dec;60(4):9-19. PubMed PMID: 29244917. |