| Description | P110 TFA is a dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. |
| In vitro | P110 TFA对dynamin 1或其他与线粒体动态相关的蛋白无影响。在体外实验中抑制线粒体裂解、功能障碍及活性氧(ROS)的产生。通过保护线粒体完整性减少程序性细胞死亡并提高细胞活力。在帕金森病小鼠模型中减少线粒体碎片化和线粒体ROS的产生。细胞可渗透。 |
| molecular weight | 2525.8 |
| Molecular formula | C102H180F3N45O27 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL, Sonication is recommended. H2O: 50 mg/mL, Sonication is recommended. |
| References | 1. Qi et al (2013) A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J.Cell Sci. 126 789 PMID: 2. Filichia et al (2016) Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP. Sci.Rep. 13 32656 PMID: |