| Description | OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor (EC50 of 3 μM in cells), which can be used to study OGT inhibition in different human cell lines. |
| In vitro | OSMI-4 是 OGT抑制剂，它在细胞内的EC50约为3μM，可用于研究 OGT复杂的生物学功能。[1] |
| Target activity | OGT:3 μM (EC50) |
| molecular weight | 604.09 |
| Molecular formula | C27H26ClN3O7S2 |
| CAS | 2260791-14-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (74.49 mM), Sonication is recommended. |
| References | 1. Martin SES, et al. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545. 2. Balsollier C, et al. Design of OSMI-4 Analogs Using Scaffold Hopping: Investigating the Importance of the Uridine Mimic in the Binding of OGT Inhibitors. ChemMedChem. 2023;18(8):e202300001. |