| Description | Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory compound with anti-inflammatory and analgesic activity used in the study of gastric ulcers. |
| In vitro | Bermoprofen 通过喷涂由乙基纤维素和羟丙基甲基纤维素（3：2）组成的薄膜溶液对速释颗粒（IRG）进行包覆，从而获得 3 种缓释颗粒（RRGs）用于延长其作用持续时间并减少其副作用[1]。 |
| In vivo | 在体重为 2.3-3 千克的雄性白化兔中，Bermoprofen（0.04、0.4、0.1毫克/千克；口服；LPS 静脉注射后1小时给药）能够明显抑制肛温升高[2]。 |
| Synonyms | AD-1590, AJ-1590 |
| molecular weight | 296.32 |
| Molecular formula | C18H16O4 |
| CAS | 78499-27-1 |
| Storage | keep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 80 mg/mL (269.98 mM), Sonication is recommended. |
| References | 1. Mori M, et al. Prolongation of antipyretic action and reduction of gastric ulcerogenicity in the rat by controlled-release granules of bermoprofen, a new nonsteroidal anti-inflammatory drug. J Pharm Sci. 1991 Sep;80(9):876-80. 2. Nakamura H, et al. AD-1590, a potent antagonist of lipopolysaccharide-induced fever in rabbits. J Pharm Pharmacol. 1984 Mar;36(3):182-6. |