| Description | Oseltamivir phosphate (GS 4104) is the phosphate salt of oseltamivir, a synthetic derivative prodrug of ethyl ester with antiviral activity. By blocking neuraminidases on the surfaces of influenza viruses, oseltamivir interferes with host cell release of complete viral particles. |
| In vitro | Oseltamivir phosphate 、抗Neu1抗体以及针对基质金属蛋白酶-9的特异性抑制剂能够阻断EGF激活的TNBC MDA-MB-231细胞中与Neu1活性相关的过程[2]。奥司他韦通过阻止病毒化学切断与宿主细胞的联系，减缓流感（flu）病毒在体内细胞间的传播。 |
| In vivo | Oseltamivir phosphate 单药治疗可能对TNBC（三阴性乳腺癌）[2]具有有效的治疗作用。在小鼠中，它对由H5N1和H9N2流感病毒引起的感染具有疗效[3]。经口服后，前药（Oseltamivir phosphate ）可从胃肠道迅速吸收，并迅速转化为活性代谢产物OC。在所有患者群体中，OC具有高生物利用度，并以足够的浓度系统性分布至感染部位，抑制一系列流感病毒神经氨酸酶[4]。 |
| Cell experiments | Cells are incubated in 96-well plates (5,000 cells/well) and allowed to adhere for 24 hours in 1× DMEM media containing 10% FCS. The media are replaced with fresh DMEM media containing 5% FCS with or without various concentrations of tamoxifen or OP for indicated time periods. Cell viability is tested using WST-1 cell proliferation assay.(Only for Reference) |
| Synonyms | GS 4104, 磷酸奥司他韦 |
| molecular weight | 410.4 |
| Molecular formula | C16H28N2O4·H3PO4 |
| CAS | 204255-11-8 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (24.37 mM) H2O: 80 mg/mL (194.93 mM), Sonification is recommended. |
| References | 1. Li W, et al. Antimicrob Agents Chemother. 1998, 42(3):647-53. 2. Haxho F, et al. Breast Cancer (Dove Med Press). 2014, 6:191-203. 3. Leneva IA, et al. Antiviral Res. 2000, 48(2):101-15. 4. Davies BE, et al. J Antimicrob Chemother. 2010, 65 Suppl 2:ii5-ii10. 6. Huang H, et al. Transplacental transfer of Oseltamivir phosphate and its metabolite Oseltamivir carboxylate using the ex vivo human placenta perfusion model in Chinese Hans population. J Matern Fetal Neonatal Med. 2016 Aug 8:1-5. 7. Li P, et al. A Simple and Robust Approach for Evaluation of Antivirals Using a Recombinant Influenza Virus Expressing Gaussia Luciferase. Viruses. 2018 Jun 13;10(6). pii: E325. 8. WEI X U, Shuai X, Jing P, et al. The antihistamine drugs carbinoxamine maleate and chlorpheniramine maleate exhibit potent antiviral activity against a broad spectrum of influenza viruses[J]. Frontiers in Microbiology. 2018 Nov 6;9:2643. |
| Citations | 1. WEI X U, Shuai X, Jing P, et al. The antihistamine drugs carbinoxamine maleate and chlorpheniramine maleate exhibit potent antiviral activity against a broad spectrum of influenza viruses. Frontiers in Microbiology. 2018 Nov 6;9:2643 |