| Description | Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. |
| Target activity | GlyT2:16 nM(human) |
| molecular weight | 448.983 |
| Molecular formula | C24H33ClN2O4 |
| CAS | 495076-64-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 8 mg/mL DMSO: 60 mg/mL (133.64 mM) |
| References | 1. W L Caulfield, et al.The first potent and selective inhibitors of the glycine transporter type 2.J Med Chem. 2001 Aug 16;44(17):2679-82. |