| Description | LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a. |
| In vivo | LY2365109 hydrochloride 在老鼠中提高了癫痫阈值[2]。LY2365109 hydrochloride（0.3-30 mg/kg; p.o.）导致脑脊液中甘氨酸水平呈剂量依赖性提高[1]。 |
| Target activity | GlyT1 (human):15.8 nM nM |
| Synonyms | LY2365109盐酸盐 |
| molecular weight | 421.91 |
| Molecular formula | C22H28ClNO5 |
| CAS | 1779796-27-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/mL (71.11 mM) |
| References | 1. Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54. 2. Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65. |