| Description | o-Phenanthroline monohydrate (1, 10-Phenanthroline monohydrate) is an inhibitor of metallopeptidases, inhibits zinc-dependent hydrolysis of Fa-Gly-Leu-NH2 by B. subtilis neutral protease and B. thermoproteolyticus thermolysin. |
| Synonyms | Phenanthroline monohydrate, 1, 10-Phenanthroline monohydrate, 邻菲罗啉 |
| molecular weight | 198.22 |
| Molecular formula | C12H10N2O |
| CAS | 5144-89-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (252.24 mM), Sonication is recommended. |
| References | 1. Feder J , Garrett L R , Kochavi D . Studies on the inhibition of neutral proteases by 1,10-phenanthroline[J]. Biochimica et Biophysica Acta, 1971, 235(2):370-377. 2. Granato M Q , de Araújo Massapust, Priscila, Rozental S , et al. 1,10-Phenanthroline Inhibits the Metallopeptidase Secreted byPhialophora verrucosaand Modulates its Growth, Morphology and Differentiation[J]. Mycopathologia, 2015, 179(3-4):231-242. |
| Citations | 1. Wang Y, Wu Z, Wang Z, et al.Analyses of the Antibiofilm Activity of o-Phenanthroline Monohydrate against Enterococcus faecalis and Staphylococcus aureus and the Mechanisms Underlying These Effects.ACS Infectious Diseases.2024 |