| Description | MMP2-IN-3 is a potent inhibitor of matrix metalloproteinases (MMP-2) (IC50: 31 μM). MMP2-IN-3 inhibits MMP-9 and MMP-8 with IC50s of 26.6 and 32 μM, respectively. |
| Target activity | MMP9:26.6 ± 2.3 μM, MMP13:>100 μM, MMP8:32 ± 4 μM, MMP2:31 ± 5 μM |
| molecular weight | 355.43 |
| Molecular formula | C23H21N3O |
| CAS | 897799-81-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 12 mg/mL (33.76 mM) |
| References | 1. Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 ; 28(3):115257. |