| Description | NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors. |
| In vitro | NSC622608 blocked VISTA signaling in vitro, enhanced T-cell proliferation, and restored T-cell activation in the presence of VISTA-expressing cancer cell lines[1]. |
| molecular weight | 322.24 |
| Molecular formula | C9H12BrN3OS2 |
| CAS | 2593254-90-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 4.67 mg/mL (14.48 mM), Sonication is recommended. |
| References | 1. Gabr MT, Gambhir SS. Discovery and Optimization of Small-Molecule Ligands for V-Domain Ig Suppressor of T-Cell Activation (VISTA). J Am Chem Soc. 2020 Sep 23;142(38):16194-16198. |
| Citations | 1. Tang D, Zhao L, Yan F, et al.Expression of VISTA regulated via IFN-γ governs endogenous T-cell function and exhibits correlation with the efficacy of CD19 CAR-T cell treated B-malignant mice.Journal for ImmunoTherapy of Cancer.2024, 12(6). |