| Description | NSC2805 is an inhibitor of WWP2, an E3 ubiquitin ligase with an IC50 of 0.38 μM. NSC2805 can be used in anticancer studies. |
| In vitro | NSC2805显著降低WWP2、WWP1和Nedd4蛋白的活性，并强效抑制WWP2依赖的PTEN泛素化[1]。 |
| Synonyms | 2-(2,5-dihydroxy-4-methylphenyl)-5-methylbenzene-1,4-diol |
| molecular weight | 246.26 |
| Molecular formula | C14H14O4 |
| CAS | 4371-34-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 2.46 mg/mL (10.01 mM) |
| References | 1. Jessica E Watt, et al. Discovery of Small Molecule WWP2 Ubiquitin Ligase Inhibitors. Chemistry. 2018 Dec 3;24(67):17677-17680. |