| Description | NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM). |
| In vivo | 给予NS-3-008抑制了健康小鼠肝脏中G0s2的表达。相比之下，NS-3-008对野生型假手术及5/6Nx小鼠的MBP无影响。NS-3-008作为新型G0s2抑制剂，研究表明，该抑制剂的给予改善了野生型5/6Nx小鼠的肾功能障碍。 |
| Target activity | G0s2:2.25 μM |
| Synonyms | NS-3-008 HCl |
| molecular weight | 269.81 |
| Molecular formula | C14H24ClN3 |
| CAS | 1172854-54-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 120 mg/mL (444.76 mM), Sonication is recommended. H2O: 125 mg/mL (463.29 mM), Sonication is recommended. |
| References | 1. Matsunaga N, et al. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EBioMedicine. 2016 Nov;13:262-273. |