| Description | Norwogonin (5,7,8-Trihydroxyflavone), isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (IC50: 31.83 μg/ml). |
| In vitro | Norwogonin（0.4、2、10及50 μg/mL；48小时）在Vero细胞中抑制肠道病毒71型（EV71）的复制，并防止EV71感染引起的细胞毒性。特别地，Norwogonin（50 μg/mL；48小时）显著降低病毒VP2蛋白的表达，并强烈减少48小时时EV71 NCR基因的表达。 |
| Target activity | EV71:31.83 μg/ml |
| Synonyms | 5,7,8-Trihydroxyflavone, 去甲汉黄芩素 |
| molecular weight | 270.24 |
| Molecular formula | C15H10O5 |
| CAS | 4443-09-8 |
| Storage | keep away from direct sunlight|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 20 mg/mL (74.01 mM) |
| References | 1. Choi HJ, et al. Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71. Biomol Ther (Seoul). 2016 Sep 1;24(5):552-8. |
| Citations | 1. Ni Z, Ma H, Li X, et al.Wogonin alleviates BaP‐induced DNA damage and oxidative stress in human airway epithelial cells by dual inhibiting CYP1A1 activity and expression.Environmental Toxicology.2023 |