| Description | JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling |
| In vitro | JLK6 markedly reduced Aβ secreted from HEK293 cells. Immunological characterization indicated that one fragment was labelled with a specific antibody against the Asp1 residue of Aβ[1]. |
| Target activity | γ-secretase:10 μM-1 mM |
| molecular weight | 225.63 |
| Molecular formula | C10H8ClNO3 |
| CAS | 62252-26-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 22 mg/mL (97.50 mM) Ethanol: 5 mg/mL (22.16 mM) |
| References | 1. Petit A, Pasini A, Alves Da Costa C, et al. JLK isocoumarin inhibitors: Selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. Journal of neuroscience research, 2003, 74(3): 370-377. |