| Description | Norlichexanthone has the potential to treat and/or prevent lifestyle-related diseases such as type 2 diabetes, metabolic syndrome, atherosclerosis and cardiovascular disease. Norlichexanthone has antibacterial and antimalarial activity, it has strong activity against Bacillus subtilis with an IC50 range of 1- 5uM, and also has strong inhibitory effect on the growth of methicillin-resistant Staphylococcus aureus with an IC50 of 20.95±1.56 uM. |
| In vitro | P16菌株的丁醇提取物展示了特定活性，并通过活性指导的分离过程中分离出了活性化合物Norlichexanthone。Oil red O染色结果显示，Norlichexanthone诱导ST-13细胞内的脂肪生成。通过观察到Norlichexanthone剂量依赖性增加脂肪酸结合蛋白和过氧化物酶体增殖物激活受体γ（PPARγ）的mRNA表达，支持其诱导分化活性，这些均为脂肪细胞分化的标志。西方印迹分析证明，该化合物剂量依赖性地增强了脂联素蛋白的分泌。在经Norlichexanthone处理的ST-13细胞中，也观察到脂联素的mRNA表达增加。使用放线菌素D处理可以阻断Norlichexanthone对脂联素mRNA表达的增强作用，这表明其作用是通过增加转录实现的。荧光素酶报告基因分析表明，Norlichexanthone不太可能是PPARγ的激动剂，这意味着其作用机制可能与通过激活PPARγ上调脂联素表达的噻唑烷二酮不同。 |
| Target activity | Methicillin-resistant Staphylococcus aureus:20.95±1.56uM |
| molecular weight | 258.23 |
| Molecular formula | C14H10O5 |
| CAS | 20716-98-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Norlichexanthone isolated from fungus P16 promotes the secretion and expression of adiponectin in cultured ST-13 adipocytes. Med Chem. 2011 Jul;7(4):250-6. 2. SnPKS19 encodes the polyketide synthase for alternariol mycotoxin biosynthesis in the wheat pathogen Parastagonospora nodorum. Appl Environ Microbiol. 2015 May 29. 3. Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp. Fitoterapia. 2012 Jan;83(1):209-14. |