| Description | NGP555 is a modulator of γ-secretase. |
| In vitro | NGP555在细胞培养中有效降低Aβ42（9 nM），同时增加Aβ的较短形式。 |
| In vivo | NGP555表现出良好的口服生物利用度，并且能够穿透血脑屏障，其在小鼠体内的脑：血浆比率约为0.93。经NGP555处理的转基因小鼠在行为表现上显示出显著的保护效果，与对照组转基因小鼠相比，性能下降超过65%较少（P<0.005）。NGP555显著降低了脑脊液中的Aβ42水平，在服药后8至10小时的时间点上尤为明显。通过将Aβ42的减少与Aβ38的增加相结合，NGP555在1.87 mg/kg及以上剂量时有效提高了脑脊液中Aβ38/42的比例。 |
| molecular weight | 406.52 |
| Molecular formula | C23H23FN4S |
| CAS | 1304630-27-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (61.50 mM), Sonication is recommended. |
| References | 1. Kounnas MZ, et al. NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents. Alzheimers Dement (N Y). 2017 Jan;3(1):65-73. |