| Description | Golgicide A is a potent and rapidly reversible GBF1 inhibitor. |
| In vitro | Golgicide A通过IC50为3.3 μM的效率抑制志贺毒素对蛋白质合成的影响。Golgicide A降低GBF1介导的Arf1激活，阻断可溶性和膜锚定蛋白质的分泌，从而干扰毒素的逆行运输。[1] 此外，Golgicide A在FLRP1细胞和J6/JFH1细胞中降低HCV RNA水平，并导致NS5A的重新分布和J6/JFH1细胞中感染性病毒颗粒的积累。[2] |
| molecular weight | 284.3 |
| Molecular formula | C17H14F2N2 |
| CAS | 1139889-93-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 14.2 mg/mL (50 mM) |
| References | 1. Sáenz JB, et al. Nat Chem Biol. 2009, 5(3), 157-16 2. Matto M, et al. J Virol. 2011, 85(2), 946-956. |