| Description | NGI-1 (ML414) is a a cell-permeable inhibitor of oligosaccharyltransferase (OST).can effectively reduce virus infectivity without affecting cell viability. |
| In vitro | 在非小细胞肺癌细胞中，NGI-1阻断了表皮生长因子受体（EGFR）糖蛋白的细胞表面定位和信号传导，但仅在那些依赖EGFR（或成纤维细胞生长因子，FGFR）生存的细胞系中选择性地抑制增殖[1]。 |
| Synonyms | ML414 |
| molecular weight | 394.51 |
| Molecular formula | C17H22N4O3S2 |
| CAS | 790702-57-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 160 mg/mL (405.57 mM) |
| References | 1. Lopez-Sambrooks C , Shrimal S , Khodier C , et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells[J]. Nature Chemical Biology, 2016. 2. Lu H , Cherepanova N A , Gilmore R , et al. Targeting STT3A-oligosaccharyltransferase with NGI-1 causes herpes simplex virus 1 dysfunction[J]. The FASEB Journal, 2019. |