| Description | MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAM |
| In vitro | MFZ 10-7 hydrochloride has approximately 1150- and 3000-fold lower affinity for MAO-B and TXA2, respectively, compared to mGluR5[1]. |
| In vivo | MFZ 10-7 hydrochloride can lower oral sucrose self-administration rate but has no effect on total sucrose intake[1]. |
| Target activity | mGluR5 (rat):0.67 nM (ki) |
| molecular weight | 272.71 |
| Molecular formula | C15H10ClFN2 |
| CAS | 1779796-36-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Thomas M Keck, et al. A Novel mGluR5 Antagonist, MFZ 10-7, Inhibits Cocaine-Taking and Cocaine-Seeking Behavior in Rats. Addict Biol . 2014 Mar;19(2):195-209. |