| Description | Nephrin is a cell surface signaling receptor protein that regulates podocyte function and plays a role in β-cell survival signaling; it is a protein necessary for the proper functioning of the renal filtration barrier. Nephrin belongs to a family of highly conserved proteins with a well characterized function as modulators of cell adhesion and guidance, and nephrin may have a role in metabolic pathways linked to podocyte and pancreatic β-cell survival. Nephrin is associated and partly co-localized with PI3-kinase in mouse islet β-cells and the mouse pancreatic beta-cell line (βTC-6 cells). Nephrin silencing abolishes Akt activation and increased susceptibility of cells to apoptosis. Glucose-induced changes in nephrin signaling may contribute to gradual pancreatic β-cell loss in type 2 diabetes. This suggests a role for nephrin as an independent modulator of podocyte and pancreatic β-cell nutrient sensing in the fasting state and the potential of nephrin as a drug target in diabetes. |
| molecular weight | 460.743 |
| Molecular formula | C30H52O3 |
| CAS | 65136-96-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Li X, Chuang PY, D'Agati VD, Dai Y, Yacoub R, Fu J, Xu J, Taku O, Premsrirut PK, Holzman LB, He JC. Nephrin Preserves Podocyte Viability and Glomerular Structure and Function in Adult Kidneys. J Am Soc Nephrol. 2015 Oct;26(10):2361-77. doi: 10.1681/ASN.2014040405. Epub 2015 Feb 2. PubMed PMID: 25644109; PubMed Central PMCID: PMC4587684. 2. Li X, He JC. An update: the role of Nephrin inside and outside the kidney. Sci China Life Sci. 2015 Jul;58(7):649-57. doi: 10.1007/s11427-015-4844-1. Epub 2015 Apr 29. Review. PubMed PMID: 25921941. 3. Kapodistria K, Tsilibary EP, Politis P, Moustardas P, Charonis A, Kitsiou P. Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling. Mol Cell Endocrinol. 2015 Jan 15;400:112-28. doi: 10.1016/j.mce.2014.11.003. Epub 2014 Nov 28. PubMed PMID: 25448064. 4. Wang P, Li M, Liu Q, Chen B, Ji Z. Detection of urinary podocytes and nephrin as markers for children with glomerular diseases. Exp Biol Med (Maywood). 2015 Feb;240(2):169-74. doi: 10.1177/1535370214548995. Epub 2014 Sep 21. PubMed PMID: 25245074; PubMed Central PMCID: PMC4935320. |