| Description | NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin. |
| In vitro | In vitro kinase assay showed that NCC007 inhibited CKIα and CKIδ with an IC50 of 1.8 and 3.6 μM. |
| In vivo | NCC007 lengthened the period of mouse behavioral rhythms in vivo. |
| Target activity | CKIα:1.8 μM, CKIδ:3.6 μM |
| molecular weight | 447.5 |
| Molecular formula | C22H28F3N7 |
| CAS | 2342583-66-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 120 mg/mL (268.16 mM), Sonication is recommended. |
| References | 1. Lee JW, et al. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase I伪 and 未. J Med Chem. 2019 Feb 28;62(4):1989-1998. |