| Description | NAZ2329 is the first cell-permeable inhibitor of the R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), which is a variant and preferentially inhibits PTPRZ (IC50=7.5 μM for hPTPRZ1) and PTPRG (IC50=4.8 μM for hPTPRG) compared to other PTPs. NAZ2329 inhibited the tumor growth of glioblastoma cells and exhibited stem cell-like properties compared to the whole (D1 + D2) fragment of PTPRZ. |
| molecular weight | 501.56 |
| Molecular formula | C21H18F3NO4S3 |
| CAS | 2809469-05-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |