| Description | 1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed to OGD, which may be relevant to the promotion of PKA and ERK signaling pathway. 3. Nardosinone enhances staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying both the MAP kinase-dependent and -independent signaling pathways of dbcAMP and staurosporine. 4. The enhancement of NGF-induced neurite outgrowth from PC12D cells by Nardosinone involves activation of a down-stream step of the MAP kinase-dependent cascade of NGF coupled with PKC. |
| Synonyms | 苷松新酮, 甘松新酮 |
| molecular weight | 250.33 |
| Molecular formula | C15H22O3 |
| CAS | 23720-80-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 46 mg/mL (183.8 mM) Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble |
| References | 1. Du M , Huang K , Gao L , et al. Nardosinone Protects H9c2 Cardiac Cells from Angiotensin II-induced Hypertrophy[J]. Journal of Huazhong University of Science and Technology, 2013, 33(6):822-826. |