| Description | Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A the ARC motor neuron B16 and the abdominal neuron L10. |
| In vitro | Myomodulin 在振荡心内神经元中减少周期并增加尖峰频率，增强了超极化激活的阳离子电流，并抑制了电生理学上的Na/K泵[1]。一种myomodulin肽被认为介导药用水蛭Hirudo medicinalis中央神经系统的Leydig内神经元受刺激时巨型胶质细胞的响应。该肽诱发的膜外向电流（EC50约2μM）既不表现出脱敏也不表现出任何衰减迹象，并且促使胶质细胞膜的K+传导性增加[2]。Myomodulin 在多种生物中调节离子通道，包括Aplysia、Lymnaea和Pleurobranchaea。Myomodulin 差异性调制钾电流并将Ca2+电流的振幅降低了20%[3]。 |
| Synonyms | 肌调蛋白 |
| molecular weight | 846.12 |
| Molecular formula | C36H67N11O8S2 |
| CAS | 110570-93-9 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Tobin AE, et al. Myomodulin increases Ih and inhibits the NA/K pump to modulate bursting in leech heart interneurons. J Neurophysiol. 2005 Dec;94(6):3938-50. |