| Description | AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39. |
| In vitro | AB-680能够抑制可溶性hCD73（IC50：0.043 nM），同时也能在CHO细胞中抑制hCD73。AB-680在人体和小鼠的CD8+ T细胞以及hPBMC中抑制CD73，对应的IC50分别是0.070、0.008、0.66和0.011 nM。 |
| Target activity | CD73:4.9 pM (ki;human), CD73:43 pM (Soluble hCD73) |
| molecular weight | 580.82 |
| Molecular formula | C20H24ClFN4O9P2 |
| CAS | 2105904-82-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 180 mg/mL (309.91 mM), Sonication is recommended. |
| References | 1. Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy. |