| Description | Mycophenolic Acid Impurity (5,7-dihydroxy-4-methylphthalide) is an an immunosuppresant drug and potent anti-proliferative, and can be used in place of the older anti-proliferative azathioprine. It is usually used as part of triple therapy including a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. It is also useful in research for the selection of animal cells that express the E. coli gene coding for XGPRT (xanthine guanine phosphoribosyltransferase). |
| Synonyms | 马替麦考酚酸杂质, 5,7-dihydroxy-4-methylphthalide |
| molecular weight | 180.16 |
| Molecular formula | C9H8O4 |
| CAS | 27979-57-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 65 mg/mL (360.79 mM) |
| References | 1. Bullingham, R., Nicholls, A., & Kamm, B. (1998). Clinical Pharmacokinetics of Mycophenolate Mofetil. Clinical Pharmacokinetics, 34(6), 429-455. doi: 10.2165/00003088-199834060-00002 2. Lee, W., Gu, L., Miksztal, A., Chu, N., Leung, K., & Nelson, P. (1990). Bioavailability improvement of mycophenolic acid through amino ester derivatization. Pharm Res, 7(2), 161-6. |