| Description | BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells. BMS-502 stimulates immune responses in a dose-dependent manner and can be used to study immune-related diseases. |
| Target activity | DGK ζ:2.1nM, DGK α:4.6 nM |
| molecular weight | 516.5 |
| Molecular formula | C27H22F2N6O3 |
| CAS | 2407854-18-4 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (154.89 mM), Sonication is recommended. |
| References | 1. Chupak L, et al. Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization. ACS Med Chem Lett. 2023 Jun 12;14(7):929-935. |