| Description | MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM. |
| In vitro | MRZ 2-514 抑制峰值AMPA诱导的电流，IC50值为72.7 μM[1]。 |
| In vivo | MRZ 2-514在小鼠 MES模型中显示出抗惊厥作用，并且这种效应被probenecid加强[1]。 |
| Target activity | AMPA:72.7 μM, NMDA:33 μM (Ki) |
| Synonyms | 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one |
| molecular weight | 308.09 |
| Molecular formula | C11H6BrN3O3 |
| CAS | 202808-11-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 18.33 mg/ml (59.51 mM) |
| References | 1. Parsons CG, et al. Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization. Journal of Pharmacology and Experimental Therapeutics (1997), 283(3), 1264-1275 |