| Description | Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone significantly inhibits the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages. |
| In vitro | 5-hydroxy-7,8-dimethoxyflavone significantly decreased TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide (NO) secretions from LPS/IFN-gamma stimulated RAW 264.7 cells[1]. |
| In vivo | 5-hydroxy-7,8-dimethoxyflavone can significantly prolong the survival time of hypoxic mice[2]. |
| Animal experiments | The chemical constituents, isolated and purified by column chromatography from Saussurea invo lucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice[2]. |
| Synonyms | 5-羟基-7,8-二甲氧基黄酮, 5-hydroxy-7,8-dimethoxyflavone |
| molecular weight | 298.29 |
| Molecular formula | C17H14O5 |
| CAS | 3570-62-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (33.52 mM) |
| References | 1. Chao W W , Kuo Y H , Lin B F . Anti-inflammatory Activity of New Compounds from Andrographis paniculata by NF-??B Transactivation Inhibition[J]. Journal of Agricultural and Food Chemistry, 2010, 58(4):2505-2512. 2. Jing L L , He L , Fan P C , et al. [Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata][J]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2015, 38(1):89-92. |