| Description | MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory effects through upregulation of BMPR-II and inhibition of NFκB signaling. mnTBAP chloride is a manganese porphyrin complex with antioxidant properties and has potential for use in the study of fibrotic responses in chronic kidney diseases (CKDs). |
| In vitro | 由于其超氧化物歧化酶模拟特性，研究发现50μMMnTBAP能够以剂量依赖的方式减轻由不同浓度的百草枯经4小时曝露造成的伤害。MnTBAP也能在剂量依赖的方式下保护内皮细胞免受百草枯的伤害。MnTBAP的保护效果似乎是由于其细胞内超氧化物清除活性所致，因为锌形式和CuZnSOD都无法保护细胞免受百草枯引起的伤害。[1] |
| In vivo | 地方性施用MnTBAP显著地并且依剂量减少了卡拉胶引发的爪肿胀，在所有时间点上呈剂量依赖性降低，这与其超氧化物歧化酶模拟特性有关。MnTBAP同样引起了爪中髓过氧化物酶活性的显著剂量依赖性降低，并且预防了组织学损伤。免疫组化分析用于硝基酪氨酸在卡拉胶处理的大鼠爪中显示了阳性染色。[2] |
| Synonyms | Mn(III)TBAP |
| molecular weight | 876.13 |
| Molecular formula | C48H25ClMnN4O8 |
| CAS | 55266-18-7 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (102.4 mM), Sonication is recommended. 0.5 M NaOH: 18.0 mg/mL (20.5 mM), Sonication is recommended. 1M NaOH: 9.0 mg/mL (10.2 mM), when pH is adjusted to 8 with NaOH. Sonication is recommended. |
| References | 1. Day BJ, et al. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro. J Pharmacol Exp Ther. 1995;275(3):1227-1232. 2. Cuzzocrea S, et al. Protective effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in paw oedema induced by carrageenan in the rat. Biochem Pharmacol. 1999;58(1):171-176. 3. Yu J, et al. MnTBAP Therapy Attenuates Renal Fibrosis in Mice with 5/6 Nephrectomy. Oxid Med Cell Longev. 2016;2016:7496930. 4. Zhou Q, et al. MnTBAP increases BMPR-II expression in endothelial cells and attenuates vascular inflammation. Vascul Pharmacol. 2016;84:67-73. 5. Faulkner KM, et al. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. J Biol Chem. 1994;269(38):23471-23476. |