| Description | ML-298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM). |
| Target activity | PLD2:355 nM |
| Synonyms | ML298, CID53393915 |
| molecular weight | 432.44 |
| Molecular formula | C22H23F3N4O2 |
| CAS | 1426916-02-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 9 mg/mL (20.81 mM) |
| References | 1. Brown K A . Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.[J]. Journal of Medicinal Chemistry, 2013, 56(6):2695. 2. Scott S A , MC O’Reilly, Daniels J S , et al. Development of a Selective, Allosteric PLD2 Inhibitor[M]. PubMed, 2010. |