| Description | Melittin Acetate (Forapin Acetate) is a PLA2 activator. Melittin Acetate stimulates the activity of the low molecular weight PLA2, while it does not increase the activity of the high molecular weight PLA2. |
| In vitro | Melittin Acetate 是来自蜂毒的免疫相关 PLA2 刺激肽。该化合物不仅能增强高分子量酶的活性[1]，还是一种对蜂毒具有细胞毒性的肽。Melittin Acetate 对 A2780CR 和 A2780 细胞表现出毒性，其 IC50 值分别为 4.5 和 6.8 μg/mL。此外，Melittin Acetate 显示出天然的抗细菌、抗病毒和抗炎特性，并已在包括胃癌、乳腺癌、卵巢癌、肝癌、前列腺癌、宫颈癌和肺癌等多种癌症细胞系中证明具有多样的抗癌效果。Melittin Acetate 作为一种两亲性溶血肽，其潜在的抗癌作用机制包括抑制细胞增殖、诱导凋亡和直接坏死。Melittin Acetate 还能通过抑制 PI3K/Akt/mTOR 信号通路阻止 EGF 诱导的细胞侵袭，这一点主要与乳腺癌细胞相关[2]。 |
| Synonyms | Melittin Acetate(20449-79-0 Free base), Forapin Acetate |
| molecular weight | 2906.51 |
| Molecular formula | C133H233N39O33 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Steiner MR, et al. Responses of purified phospholipases A2 to phospholipase A2 activating protein (PLAP) and Melittin. Biochim Biophys Acta. 1993 Feb 10;1166(1):124-30. 2. Alonezi S, et al. Metabolomic Profiling of the Effects of Melittin on Cisplatin Resistant and Cisplatin Sensitive Ovarian Cancer Cells Using Mass Spectrometry and Biolog Microarray Technology. Metabolites. 2016 Oct 13;6(4). pii: E35. |