| Description | ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinase (DMPK) properties for systemic dosing in rodents. |
| Target activity | mGluR5 (rat):8.03 nM (pEC50), mGluR5 (rat):9.3 nM (EC50) |
| molecular weight | 310.32 |
| Molecular formula | C18H15FN2O2 |
| CAS | 1428630-86-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 27.5 mg/mL (88.62 mM) |
| References | 1. Zhou Y , Chun A , Gogliotti R D , et al. Pure Positive Allosteric Modulators (PAMs) of mGlu5 with Competitive MPEP-Site Interaction[M]// Probe Reports from the NIH Molecular Libraries Program. PubMed, 2010. |